Association between serum concentration of natriuretic peptides and perceived withdrawal symptoms in opiate maintenance

作者：Schuster Rilana^*; Glahn Alexander; Heberlein Annemarie; Rehme Marie Kathrin; Kleimann Alexandra; Lichtinghagen Ralf; Koopmann Anne; Bleich Stefan; Hillemacher Thomas

来源：Heroin Addiction and Related Clinical Problems, 2017, 19(3): 5-10.

• atrial natriuretic peptide
• brain natriuretic peptide
• diamorphine
• natriuretic peptides
• opiate dependence
• opiate maintenance treatment

Background: Volume-regulation peptides indirectly influence the hypothalamic pituitary adrenal (HPA) axis and thereby also the strength of craving, withdrawal symptoms and the potential risk of relapse. Aims: The primary objective of the present study was to examine the serum levels of atrial and brain natriuretic peptides (ANP and BNP) in patients undergoing different opiate-based maintenance treatments. Methods: We compared two groups of patients receiving levomethadone (n=55) or else diamorphine (n=28) treatment, with a third, healthy control group (n=51). Results: We found a potential association between withdrawal symptoms measured with the Short Opiate Withdrawal Scale (SOWS) and serum levels of ANP and BNP in opiate-addicted patients undergoing diamorphine maintenance treatment. Conclusions: Differently from methadone maintenance, diamorphine seems to be unable to suppress natriuretic peptides levels, which, in our patients, reflect the amount of opioid withdrawal symptomatology.

• 出版日期2017-6
• 单位上海市精神卫生中心