Nephrotoxic effect of tetradifon in rats: A biochemical and histomorphometric study

作者：Badraoui Riadh^*; Ben Nasr Hmed; Louati Rim; Ellouze Feriel; Rebai Tarek

来源：Experimental and Toxicologic Pathology, 2012, 64(6): 645-650.

DOI：10.1016/j.etp.2010.12.008

• Nephrotoxicity
• Biochemical parameters
• Tetradifon
• Histomorphometry
• Rat
• Kidney glomeruli

The effects of subchronic exposure to tetradifon on biochemical related kidney toxicological parameters [creatinine (CRT), urea, and uric acid (UA)] were examined. Oxidative stress in kidney tissue was also assessed by measuring vitamin C (VitC) content and antioxidant enzyme activities [superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)]. Tetradifon was administered orally to 12 rats at a cumulative dose of 24.3 mg/kg for 12 weeks. Twelve additional rats, no treated, have served as control. Control and treated animals were sacrificed after 6 or 12 weeks. For each group, kidneys were examined for morphometric changes. Results showed that tetradifon induced significant increases in CRT and urea, and decrease in UA. Morphometrically, while mean glomerular volume decreased percentage of sclerosed glomeruli increased in treated rats. Index of interstitial fibrosis was significantly higher. Moreover, renal antioxidant enzyme (SOD and GPx) activities and VitC content decreased. We concluded that tetradifon possessed nephrotoxic by promoting kidney morphometric and functional damage and depleting renal antioxidant defense system in rats.

• 出版日期2012-9