科研之友
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摘要
The biodegradable behaviors of monofilament suture made from bacterial biopolyester poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P3/4HB) was investigated both in lipase solution and by implant into rat tergal muscles. Results showed that the monofilament Suture lost its tensile strength gradually accompanied by decrease of molecular weight. The suture retained similar to 65% of its original strength after lipase degradation for 12 weeks, whereas the molecular weight decreased from 4.5 x 10(5) to 3.8 x 10(5). However, the crystallinity of the suture, after lipase degradation for 12 weeks, increased from 27 to 33%. This may ascribe to improve orientation arrangement of molecular chain in the monofilament after the fragment from amorphous regions dissolved in the buffer solution. The roughness of surface morphology increased with degradation. Rat implantation showed no remarkable tissue responses during in vivo degradation. Foreign body reactions were much milder than chromic catgut, which is one of the most common commercially available sutures.
- 出版日期2010-2
- 单位汕头大学
