A review on comparative study of PPI and PAMAM dendrimers

作者：Kaur Daljeet; Jain Keerti; Mehra Neelesh Kumar; Kesharwani Prashant; Jain Narendra K^*

来源：Journal of Nanoparticle Research, 2016, 18(6): 146.

DOI：10.1007/s11051-016-3423-0

• Dendrimers
• PPI
• PAMAM
• Drug delivery
• Synthesis
• Properties
• Toxicity
• Biomedical applications

Dendrimers are hyperbranched, monodispersed macromolecules with multivalent functional end groups. Dendrimers have been explored as carrier for many drugs like anticancer, antiviral, antimalarial, antiprotozoal, anti tubercular drugs. Although a number of different types of dendrimers containing different core molecules, branching monomers and surface functional groups have been designed till date for drug delivery applications, yet the poly(propyleneimine) (PPI) and poly(amidoamine) (PAMAM) dendrimers have been the most explored dendrimers in this regard. In this review, we have summarized a comparative data on PPI and PAMAM dendrimers particularly relevant to their properties, synthesis, toxicity, biomedical applications and drug delivery attributes.

• 出版日期2016-6-7