Association between an 8q24 locus and the risk of colorectal cancer in Japanese

作者：Matsuo Keitaro^*; Suzuki Takeshi; Ito Hidemi; Hosono Satoyo; Kawase Takakazu; Watanabe Miki; Shitara Kohei; Komori Koji; Kanemitsu Yukihide; Hirai Takashi; Yatabe Yasushi; Tanaka Hideo; Tajima Kazuo

来源：BMC Cancer, 2009, 9(1): 379.

DOI：10.1186/1471-2407-9-379

Background: A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited.
Methods: We conducted a case-control study in 481 patients with colorectal cancer (CRC) and 962 sex-age matched non-cancer controls. Data on lifestyle factors, including diet, were obtained by self-administered questionnaire. Two 8q24 loci, rs6983267 and rs10090154, were assessed by the TaqMan method. Associations were then assessed by multivariate logistic regression models that considered potential confounders.
Results: We found an increased risk of CRC with rs6983267 but not with rs10090154. An allelic OR was 1.22 (1.04-1.44, p for trend = 0.014), which remained significant after adjustment for confounders (OR = 1.25). No statistically significant interaction with potential confounding factors was observed.
Conclusion: The polymorphism rs6983267 showed a significant association with CRC in a Japanese population. Further investigation of the biological mechanism of this association is warranted.

• 出版日期2009-10-26