Autologous Stem Cell Transplantation for T-Cell Lymphomas

作者：Giulia Perrone; Corradini Paolo^*

来源：Seminars in Hematology, 2014, 51(1): 59-66.

DOI：10.1053/j.seminhematol.2013.11.002

Peripheral T-cell lymphomas (PTCLs) are a rare and heterogeneous group of T-cell malignancies characterized by a very poor outcome. The optimal treatment for PTCLs remains controversial. The role of stem cell transplantation in PTCLs has been investigated; however, no randomized control studies specifically dedicated to PTCLs are currently available. Several retrospective and-prospective studies have suggested that high-dose chemotherapy (HDT) followed by autologous stem cell transplantation (ASCT) may improve the survival in patients with chemosensitive T-cell lymphoma, either upfront or as salvage treatment. This review provides a summary of the current literature with the intent to explore the role of ASCT in various clinical scenarios.

• 出版日期2014-1