A Bio-chemical and Microbiological Appraisal on the Stability of the Second-line Anti-Tuberculosis Drug, Cycloserine in Mycobacterium tuberculosis

作者：Singh Rishan^*

来源：Journal of Pure and Applied Microbiology, 2012, 6(1): 209-211.

• Cycloserine
• Broth microdilution method
• pH
• Electon-rich
• Electron-deficient

Cycloserine (C3H6N2O2) is a second-line drug that is used to treat tuberculosis. Second-line drugs are usually administered to tuberculosis patients when treatment with first-line TB drugs fail or their effect in combination therapies fail or are adverse. Cycloserine has been associated with a number of adverse effects, mostly because of its instability and high levels of toxicity. This article is germane in that it addresses a way of eliminating the instable nature of this drug by studying this drug microbiologically and bio-chemically.

• 出版日期2012-3