An intrauterine catch-up growth regimen increases food intake and post-natal growth in rats

作者：Baik M^*; Rajasekar P; Lee M S; Kim J; Kwon D H; Kang W; Nguyen T H; Vu T T T

来源：Journal of Animal Physiology and Animal Nutrition, 2014, 98(6): 1132-1142.

DOI：10.1111/jpn.12170

• glucose
• lipid
• metabolism
• organ growth
• leptin

Nutritional conditions during the intrauterine stage are an important developmental programming factor that can affect the growth and metabolic status during foetal development and permanently alter the phenotypes of newborn offspring and adults. This study was performed to examine the effects of intrauterine catch-up growth (IUCG) on food intake, post-natal body growth and the metabolic status of offspring and growing rats. Control pregnant rats were fed ad libitum during the entire gestation period. For the IUCG regimen, pregnant rats were fed 50% of the food of the controls from pregnancy days 4 through 11 (8days), followed by ad libitum feeding from pregnancy days 12 through parturition. The birth weight of offspring was not affected by the IUCG regimen. At weaning, offspring from each treatment group were assigned to two groups and given either a normal diet or high-fat diet (HFD) for 12weeks until 103days of age. In the normal diet group, the IUCG offspring showed a 9.0% increase (P%26lt;0.05) in total food intake, were 11.2% heavier (p%26lt;0.05) at 103days of age and had an 11.0% greater (p%26lt;0.05) daily weight gain compared with control offspring. The IUCG regimen did not affect body glucose and lipid metabolism. After exposure to the HFD, the IUCG regimen has not exacerbated metabolic disorders. In conclusion, our findings suggest that the IUCG nutritional regimen during pregnancy can increase the food intake and post-natal body growth of offspring without inducing metabolic disorders such as obesity and insulin resistance. The IUCG nutritional regimen might be used to improve the food intake and post-natal body growth of domestic animals.

• 出版日期2014-12