科研之友
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摘要
The evolution of new drugs without side-effects limiting their use continues to be of great interest. The present study evaluated the anti-inflammatory activity of novel substituted quinoline based-chalcones incorporating different nitrogenous heterocyclic rings including pyrazolines, isoxazolines, and pyrimidines moieties using carrageenan induced paw edema assay. The investigation of anti-inflammatory screening revealed that five compounds, (2b, 3a, 4b, 5b and 6a) achieved significant activities with ulcer indices in the safe level. Among them, 3a displayed potent anti-inflammatory effect higher than the positive control drug, celecoxib, at the dose of 5 mg/kg.
- 出版日期2017
