Anti-depressant-like and Anti-stress-ulcer Effects of an Aqueous Extract of Lavender (Lavandula Angustifolia Mill.) on Mice

作者：Ueno Toshio^*; Masuda Hideki; Mutoh Aya; Yokogoshi Hidehiko

来源：Journal of the Japanese Society for Food Science and Technology, 2012, 59(9): 435-441.

• lavender
• stress
• depression
• gastric ulcer
• mice

Our previous study showed that the non-volatile fraction of lavender aqueous extract (LAE) had antidepressant-like effects on rats, using the forced swimming test (FST), after short-term administration (3 doses in 24 h). One of the aims of the present study was to further confirm the antidepressant-like effects of LAE on mice, using the FST, after long-term administration. Administration of LAE (500-2 500 mg/kg. p. o.) to mice once daily for 15 days significantly reduced immobility time in the FST without altering locomotor activity. In addition, 15-day repeated administration of the antidepressant drug imipramine (30 mg/kg, p.o.) showed the same tendency. These results indicate that LAE has antidepressant-like effects on mice after long-term administration. The other aim of this study was to examine the anti-stress ulcer effects of LAE on mice. Single administration of LAE (500-2 000 mg/kg, p. o.) to mice significantly inhibited gastric lesions induced by forced swimming stress. In conclusion, the present study suggests that LAE might have preventive or ameliorating effects on the typical stress-related diseases, depression and stress ulcer. (Received Feb. 16. 2012: Accepted May 17, 2012)

• 出版日期2012