A photochemical method for determining plasma homocysteine with limited sample processing

作者:Hakuna Lovemore; Escobedo Jorge O; Lowry Mark; Barve Aabha; McCallum Naneki; Strongin Robert M*
来源:Chemical communications, 2014, 50(23): 3071-3073.
DOI:10.1039/c4cc00432a

摘要

The photolytic formation of thiyl radicals allows for the selective detection of total homocysteine (tHcy) in plasma after reduction and filtering. The mechanism is based on the reduction of viologens by the alpha-amino carbon centred radical of Hcy generated by intramolecular hydrogen atom transfer (HAT) of its thiyl radical.

  • 出版日期2014