A collaborative systematic review and meta-analysis on 1278 patients undergoing percutaneous drug-eluting stenting for unprotected left main coronary artery disease

作者：Biondi Zoccai Giuseppe G L^*; Lotrionte Marzia; Moretti Claudio; Meliga Emanuele; Agostoni Pierfrancesco; Valgimigli Marco; Migliorini Angela; Antoniucci David; Carri Didier; Sangiorgi Giuseppe; Chieffo Alaide; Colombo Antonio; Price Matthew J; Teirstein Paul S; Christiansen Evald H; Abbate Antonio; Testa Luca; Gunn Julian P G; Burzotta Francesco; Laudito Antonio; Trevi Gian Paolo; Sheiban Imad

来源：American Heart Journal, 2008, 155(2): 274-283.

DOI：10.1016/j.ahj.2007.10.009

Background Cardiac surgery is the standard treatment for unprotected left main disease (ULM). Drug-eluting stent (DES) implantation has been recently reported in patients with ULM but with unclear results. We systematically reviewed outcomes of percutaneous DES implantation in ULM.
Methods Several databases were searched for clinical studies reporting on >= 20 patients and >= 6-month follow-up. The primary end point was major adverse cardiovascular events (MACEs; ie, death, myocardial infarction, or target vessel revascularization [TVR]) at the longest follow-up. Incidence and adjusted risk estimates were pooled with generic inverse variance random-effect methods (95% Cls).
Results From 823 initial citations, 16 studies were included (1278 patients, median follow-up 10 months). Eight were uncontrolled registries, 5 nonrandomized comparisons between DES and bare-metal stents and 3 nonrandomized comparisons between DES and CABG, with no properly randomized trial. Meta-analysis for DES-based PCI showed, at the longest follow-up, rates of 16.5% (11.7%-21.3%) MACE, 5.5% (3.4%-7.7%) death, and 6.5% (3.7%-9.2%) TVR. Comparison of DES versus bare-metal stent disclosed adjusted odds ratios for MACE of 0.34 (0.16-0.71), and DES versus CABG showed adjusted odds ratios for MACE plus stroke of 0.46 (0.24-0.90). Meta-regression showed that disease location predicted MACE (P =.001) and TVR (P =.020), whereas high-risk features predicted death (P =.027).
Conclusions Clinical studies report apparently favorable early and midterm results in selected patients with ULM. However, given their limitations in validity and the inherent risk for DES thrombosis, results from randomized trials are still needed to definitely establish the role of DES implantation instead of the reference treatment, surgery.

• 出版日期2008-2