Urinary levels of endocrine-disrupting chemicals, including bisphenols, bisphenol A diglycidyl ethers, benzophenones, parabens, and triclosan in obese and non-obese Indian children

作者：Xue Jingchuan; Wu Qian; Sakthivel Sivasubramanian; Pavithran Praveen V; Vasukutty Jayakumar R; Kannan Kurunthachalam^*

来源：Environmental Research, 2015, 137: 120-128.

DOI：10.1016/j.envres.2014.12.007

• Endocrine disruption
• Bisphenol
• BADGE
• Parabens
• Biomonitoring
• Children
• Obesity

Obesity has been recognized as a major global public health concern. In particular, childhood obesity is a major risk factor for other health issues, such as type 2 diabetes, in later stages of life. A few earlier studies have associated exposure to endocrine-disrupting chemicals (EDCs) with childhood obesity. There is limited information, however, on exposure to EDCs and childhood obesity in India. In this study, urinary levels of 26 EDCs were determined in 49 obese and 27 non-obese Indian children. Eleven EDCs, including 2,2-bis(4-hydroxyphenyl)propane (BPA), 4,4'-sulfonyldiphenol (BPS), methyl paraben (MeP), ethyl paraben (EtP), propyl paraben (PrP), 4-hydroxybenzoic acid (4-HB), 3,4-dihydroxybenzoic acid (3,4-DHB), triclosan (TCS), benzophenone-3 (BP3), bisphenol A diglycidyl ether (BADGE), and bisphenol A bis (2,3-dihydroxypropyl) glycidyl ether (BADGE center dot 2H(2)O) were found in > 70% of urine samples. No significant associations were found between childhood obesity and most target chemicals studied, except for 3,4-DHB, which showed a significant positive association. Urinary concentrations of 3,4-DHB were higher in obese children than in non-obese children, independent of age, sex, family income, parent education, physical activity, and urinary creatinine. Urinary concentrations of several EDCs were higher in Indian children than the concentrations reported for children in the USA and China. To our knowledge, this is the first study to report urinary concentrations of several EDCs in Indian children.

• 出版日期2015-2
• 单位河北医科大学