Phytochemical screening, anticancer and antioxidant activities of Origanum vulgare L. ssp viride (Boiss.) Hayek, a plant of traditional usage

作者：Koldas Serkan; Demirtas Ibrahim^*; Ozen Tevfik; Demirci Mehmet Ali; Behcet Lutfi

来源：Journal of the Science of Food and Agriculture, 2015, 95(4): 786-798.

DOI：10.1002/jsfa.6903

• Origanum vulgare ssp
• viride
• Origanum acutidens
• phenolics
• antioxidant
• antiproliferative

BACKGROUNDA detailed phytochemical analysis of Origanum vulgare L. ssp. viride (Boiss.) Hayek was carried out and the antioxidant activities of five different crude extracts were determined. The antiproliferative activities of the extracts were determined using the xCELLigence system (Real Time Cell Analyzer).
RESULTSDifferences between the essential oil and volatile organic compound profiles of the plant were shown. The main component of the essential oil was caryophyllene oxide, while the main volatile organic compounds were sabinene and eucalyptol as determined by HS-GC/MS. Phenolic contents of the extracts were determined qualitatively and quantitatively by HPLC/TOF-MS. Ten phenolic compounds were found in the extracts from O. vulgare and Origanum acutidens: rosmarinic acid (in highest abundance), chicoric acid, caffeic acid, p-coumaric acid, gallic acid, quercetin, apigenin-7-glucoside, kaempferol, naringenin and 4-hydroxybenzaldehyde.
CONCLUSIONThis study provides first results on the antiproliferative and antioxidant properties and detailed phytochemical screening of O. vulgare ssp. viride (Boiss.) Hayek.

• 出版日期2015-3-15