Ascending Aortic Dilatation Associated With Bicuspid Aortic Valve Pathophysiology, Molecular Biology, and Clinical Implications

作者：Tadros Thomas M; Klein Michael D^*; Shapira Oz M

来源：Circulation, 2009, 119(6): 880-890.

DOI：10.1161/CIRCULATIONAHA.108.795401

• aneurysm
• aorta
• heart defects, congenital
• valves

Ascending aortic dilatation occurs more frequently and at a younger age in patients with bicuspid aortic valves (BAV) than it does in patients with normal trileaflet aortic valves (TAV). The clinical significance of the correlation between BAV and dilatation of the ascending aorta is based on 2 factors. First, BAV is the most common congenital cardiac abnormality, occurring in 0.46% to 1.37% of the population.(1-4) Second, aortic dilatation has a propensity for dissection and rupture, making it a potentially lethal disease. Ascending aortic dilatation with BAV warrants frequent monitoring, with possible early prophylactic surgical intervention to prevent dissection or rupture. The purpose of this article is to review the etiology and natural history and to make suggestions regarding management of the disease on the basis of the limited data available.

• 出版日期2009-2-17