A highly concise and practical route to clavaminols, sphinganine and (+)-spisulosine via indium mediated allylation of alpha-hydrazino aldehyde and a theoretical insight into the stereochemical aspects of the reaction

作者：Pandey Menaka; Chowdhury Partha Sarathi; Dutta Achintya Kumar; Kumar Pradeep^*; Pal Sourav

来源：RSC Advances, 2013, 3(35): 15442-15448.

DOI：10.1039/c3ra43048k

A conceptually different approach has been employed for the synthesis of 1,2-amino alcohols by proline-catalyzed alpha-amination of aldehyde and one-pot indium mediated allylation of the crude alpha-hydrazino aldehydes. DFT based quantum chemical calculations have been performed to obtain a quantitative explanation of the stereoselectivity of the reaction.

• 出版日期2013