Flavonoids of Rosa roxburghii Tratt Act as Radioprotectors

作者：Xu, Ping^*; Zhang, Wen-Bo; Cai, Xin-Hua; Lu, Dan-Dan; He, Xiao-Yang; Qiu, Pei-Yong; Wu, Jiao

来源：Asian Pacific Journal of Cancer Prevention, 2014, 15(19): 8171-8175.

DOI：10.7314/APJCP.2014.15.19.8171

• FRT
• radioprotection
• survival rate
• AHH-1
• CFU-S

Background: To study the radioprotective effects of flavonoids from Rosa roxburghii Tratt (FRT). Materials and Methods: The radioprotective effects of FRT were investigated by examining cell viability, 30-day survival of mice and the number of colony-forming units in spleen (CFU-S) after total-body 60Co irradiation. Results: The survival rates of irradiated cells gradually increased with increasing concentrations of FRT. The survival rate was the highest at 87% with a concentration of 30 mu g/mL. Pretreatment with FRT was needed to realize its radioprotective activity in mice at the dose of 60 mg/kg. With the increasing doses of 30 mg/kg, 60 mg/kg and 120 mg/kg, the numbers of CFU-S increased, and were significantly different compared with the control group. Conclusions: Pretreatment with FRT prior to irradiation resulted in significantly higher cell survival at 24 h after 5 Gy radiation, increased 30-day survival in mice after exposure to a potentially lethal dose of 8 Gy, and resulted in a higher number of CFU-S in mice after exposure to a dose of 6 Gy. These results collectively indicate that FRT is an effective radioprotective agent.

• 出版日期2014
• 单位新乡医学院