摘要

While BALB/c mice survive infection with blood stages of Plasmodium chabaudi chabaudi (AS), 70%, of DBA/2 mice die by day 9-11 of infection, both strains controlling parasitaemia. We describe here that infection of DBA/2 mice results in extensive, multifocal hepatocyte death. Antibody neutralization of TNF-alpha prevents both liver damage and death.

  • 出版日期2008-5