Black tea and theaflavins suppress various inflammatory modulators and i-NOS mediated nitric oxide synthesis during gastric ulcer healing

作者：Adhikary Biplab; Yadav Sudhir K; Chand Saswati; Bandyopadhyay Sandip K; Chattopadhyay Subrata^*

来源：Free Radical Research, 2011, 45(7): 767-778.

DOI：10.3109/10715762.2011.579119

• CAMs
• indomethacin
• iNOS
• eNOS
• MPO
• selectins

The modulation of the cyclooxygenase-independent pathway by black tea (BT) and its constituent theaflavins (TFs) during their healing action against indomethacin-induced stomach ulceration in mice was investigated. On the 3<SUrd</SU day of its administration, indomethacin (18 mg/kg) induced maximum stomach ulceration, which was associated with increased myeloperoxidase (MPO) activity (93.3%, p < 0.001), and inducible nitric oxide synthase (iNOS) expression (1.6-fold, p < 0.001), along with augmented levels of serum nitrite (1.5-fold, p < 0.001), selectins and cell adhesion molecules (CAMs), as well as reduced endothelial nitric oxide synthase (eNOS) expression (60%, p < 0.001). Treatment with BT (40 mg/kg) and TF (1 mg/kg) for 3 days reversed these parameters and provided excellent (78--81%) ulcer healing. However, alterations of NOS expressions and levels of selectins and CAMs were only partially responsible for the excellent healing capacity (similar to similar to 80%) of omeprazole (3 mg/kg xx 3 days).

• 出版日期2011-7