Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation

作者：Shilatifard Ali^*

来源：Current Opinion in Cell Biology, 2008, 20(3): 341-348.

DOI：10.1016/j.ceb.2008.03.019

Chromosomal surfaces are ornamented with a variety of post-translational modifications of histones, which are required for the regulation of many of the DNA-templated processes. Such histone modifications include acetylation, sumoylation, phosphorylation, ubiquitination, and methylation. Histone modifications can either function by disrupting chromosomal contacts or by regulating non-histone protein interactions with chromatin. In this review, recent findings will be discussed regarding the regulation of the implementation and physiological significance for one such histone modification, histone H3 lysine 4 (H3K4) methylation by the yeast COMPASS and mammalian COMPASS-like complexes.

• 出版日期2008-6
• 单位河北医科大学