Use of transgenic mice in UDP-glucuronosyltransferase (UGT) studies

作者：Ou, Zhimin; Huang, Min; Zhao, Lizi; Xie, Wen^*

来源：Drug Metabolism Reviews, 2010, 42(1): 123-131.

DOI：10.3109/03602530903208983

• ARYL-HYDROCARBON RECEPTOR
• PREGNANE-X-RECEPTOR
• CONSTITUTIVE ANDROSTANE RECEPTOR
• MESSENGER-RNA EXPRESSION
• ORPHAN NUCLEAR RECEPTORS
• DRUG-METABOLISM
• XENOBIOTIC RESPONSE
• SIGNALING PATHWAY
• BILIRUBIN CLEARANCE
• HEPATIC EXPRESSION

Transgenic mouse models are useful to understand the function and regulation of drug-metabolizing enzymes in vivo. This article is intended to describe the general strategies and to discuss specific examples on how to use transgenic, gene knockout, and humanized mice to study the function as well as genetic and pharmacological regulation of UDP-glucuronosyltransferases (UGTs). The physiological and pharmacological implications of transcription factor-mediated UGT regulation will also be discussed. The UGT-regulating transcription factors to be discussed in this article include nuclear hormone receptors (NRs), aryl hydrocarbon receptor (AhR), and nuclear factor erythroid 2-related factor 2 (Nrf2).

• 出版日期2010-2
• 单位中山大学