Determination of eight nitrosamines in water at the ng L-1 levels by liquid chromatography coupled to atmospheric pressure chemical ionization tandem mass spectrometry

作者：Ripolles Cristina; Pitarch Elena; Sancho Juan V; Lopez Francisco J; Hernandez Felix^*

来源：Analytica Chimica Acta, 2011, 702(1): 62-71.

DOI：10.1016/j.aca.2011.06.024

• N-nitrosamines
• N-nitrosodimethylamine
• Liquid chromatography
• Tandem mass spectrometry
• Atmospheric pressure chemical ionization
• Drinking water
• Wastewater

In this work, we have developed a sensitive method for detection and quantification of eight N-nitrosamines, N-nitrosodimethylamine (NDMA), N-nitrosomorpholine (NMor), N-nitrosomethylethylamine (NMEA), N-nitrosopirrolidine (NPyr), N-nitrosodiethylamine (NDEA), N-nitrosopiperidine (NPip), N-nitroso-n-dipropylamine (NDPA) and N-nitrosodi-n-butylamine (NDBA) in drinking water. The method is based on liquid chromatography coupled to tandem mass spectrometry, using atmospheric pressure chemical ionization (APCI) in positive mode with a triple quadrupole analyzer (QqQ). The simultaneous acquisition of two MS/MS transitions in selected reaction monitoring mode (SRM) for each compound, together with the evaluation of their relative intensity, allowed the simultaneous quantification and reliable identification in water at ppt levels. Empirical formula of the product ions selected was confirmed by UHPLC-(Q)TOF MS accurate mass measurements from reference standards.

• 出版日期2011-9-19