Vitamin D and Asthma

作者：Paul Grace; Brehm John M; Alcorn John F; Holguin Fernando; Aujla Shean J; Celedon Juan C^*

来源：American Journal of Respiratory and Critical Care Medicine, 2012, 185(2): 124-132.

DOI：10.1164/rccm.201108-1502CI

• vitamin D
• asthma
• asthma morbidity

Vitamin D deficiency and asthma are common conditions that share risk factors such as African American ethnicity, inner-city residence, and obesity. This review provides a critical examination of current experimental and epidemiologic evidence of a causal association between vitamin D status and asthma or asthma morbidity, including potential protective mechanisms such as antiviral effects and enhanced steroid responsiveness. Because most published epidemiologic studies of vitamin D and asthma or asthma morbidity are observational, a recommendation for or against vitamin D supplementation as preventive or secondary treatment for asthma is not advisable and must await results of ongoing clinical trials. Should these trials confirm a beneficial effect of vitamin D, others will be needed to assess the role of vitamin D supplementation to prevent or treat asthma in different groups such as infants, children of school age, and ethnic minorities.

• 出版日期2012-1-15