Association of LT beta R gene polymorphisms with prostate volume in benign prostatic hyperplasia in the Korean population

作者：Lee S H; Kim S K; Yoo K H; Chung J H; Chang S G^*

来源：Genetics and Molecular Research, 2015, 14(4): 18607-18615.

DOI：10.4238/2015.December.28.9

• Benign prostatic hyperplasia
• Lymphotoxin beta receptor
• Polymorphism
• Prostate

The lymphotoxin-beta receptor (LT beta R) gene is involved in autoimmune disease and inflammatory disorder development, but the relationship between LT beta R and benign prostatic hyperplasia (BPH) is unclear. In total, 222 with BPH were examined for 3 single nucleotide polymorphisms [rs3759333 (-1387C/T), rs3759334 (-1326A/G), and rs2364480 (Ala172Ala)] located in the promoter and coding regions of LT beta R using direct sequencing. The genotype distributions of rs3759334 were associated with prostate volume larger than 40 g. There were significant differences between the small (< 40 g) and large (>= 40 g) group subjects [codominant 1 model: odds ratio (OR) = 4.65, 95% confidence interval (CI) = 1.95-11.09, P = 0.001; dominant model: OR = 4.91, 95% CI = 2.07-11.63, P = 0.0002; log-additive model: OR = 4.81, 95% CI = 2.05-11.24, P = 0.0001]. The allele distributions of rs3759334 were significantly associated with BPH (OR = 4.87, 95% CI = 2.16-10.99, P = 0.0001). The distribution of rs2364480 was significantly different between groups (codominant 1 model: OR = 2.17, 95% CI = 1.11-4.26, P = 0.028; dominant model: OR = 2.16, 95% CI = 1.13-4.12, P = 0.019; log-additive model: OR = 1.86, 95%CI = 1.07-3.24, P = 0.027). The allele distribution of rs2364480 was significantly associated with BPH (OR = 1.88, 95% CI = 1.08-3.30, P = 0.027). We found that LT beta R polymorphisms caused severe BPH. Thus, LT beta R may contribute to the risk of BPH development.

• 出版日期2015