Drug formulations that require less than 0.1 mL of stock solution to prepare doses for infants and children

作者：Uppal Navjeet; Yasseen Baseer; Seto Winnie; Parshuram Christopher S^*

来源：Canadian Medical Association Journal, 2011, 183(4): E246-E248.

DOI：10.1503/cmaj.100467

Intravenous doses of medications require formulations that permit accurate preparation and administration. Current equipment does not permit accurate measurement of volumes less than 0.1 mL. In a study of four hypothetical standard pediatric patients, we found that 28 common medications required less than 0.1 mL of available formulation to prepare the dose. In a clinical study of actual use in a pediatric intensive care unit (ICU), 5245 (7.4%) of 71 218 intravenous doses required preparation from less than 0.1 mL of stock solution. For 28.5% of the 1531 ICU admissions, at least one dose was prepared from a volume of less than 0.1 mL. Our findings identify a substantial source of dosing error. Correction will require revision of preparation methods, regulatory requirements and manufacturing practices.

• 出版日期2011-3-8