A green one-pot three-component cascade reaction: the synthesis of 2-amino-5,8-dihydro-3H-pyrido[2,3-D]pyrimidin-4-ones in aqueous medium

作者：Shaabani Ahmad^*; Sepahvand Heshmatollah; Boroujeni Mahmoud Borjian; Faroghi Mohammad Tayeb

来源：Molecular Diversity, 2017, 21(1): 147-153.

DOI：10.1007/s11030-016-9712-9

• Green synthesis
• Three-component reaction
• Dihydropyridopyrimidine
• Acetophenone
• 2,6-Diaminopyrimidin-4(3H)-one
• MCR

A one-pot three-component cascade reaction for the green synthesis of a new class of 2-amino-5,8-dihydro-3H-pyrido[2,3-d]pyrimidin-4-ones was developed from the condensation of aromatic aldehydes with 2,6-diaminopyrimidin-4(3H)-one and acetophenone derivatives or various cyclic ketones in the presence of a catalytic amount of sodium carbonate in a mixture of water and ethanol at 60 . This reaction led to the construction of two carbon-carbon bonds and one carbon-nitrogen bond in a single synthetic step.

• 出版日期2017-2