Memory in individuals with mild cognitive impairment in relation to APOE and CSF A beta 42

作者：Thorvaldsson Valgeir^*; Nordlund Arto; Reinvang Ivar; Blennow Kaj; Zetterberg Henrik; Wallin Anders; Johansson Boo

来源：International Psychogeriatrics, 2010, 22(4): 598-606.

DOI：10.1017/S1041610210000335

• memory
• apolipoprotein E
• amyloid beta 42
• longitudinal study

Background: The epsilon 4 allele of the apolipoprotein E (APOE) gene and low levels of cerebrospinal fluid (CSF) amyloid beta-proteins 42 (A beta) have previously been associated with increased risk of cognitive decline in old age. In this study we examine the interaction of these markers with episodic memory in a sample identified as having mild cognitive impairment (MCI).
Methods: The sample (N = 149) was drawn from the Gothenburg MCI study and measured according to three free recall tests on three occasions spanning over four years. Second-order Latent Curve Models (LCM) were fitted to the data.
Results: Analyses accounting for age, gender, education, APOE, A beta 42, and interaction between APOE and A beta 42 revealed that the epsilon 4 allele was significantly associated with level of memory performance in the presence of low A beta 42 values (<= 452 ng/L). Associations between memory performance and A beta 42 were significant among the epsilon 4 carriers but not among the non-carriers. The A beta 42 marker was, however, significantly associated with changes in memory over the study time period in the total sample.
Conclusion: The findings support the hypothesis of an interactive effect of APOE and A beta 42 for memory decline in MCI patients.

• 出版日期2010-6