Wheel running decreases the positive reinforcing effects of heroin

作者：Smith Mark A^*; Pitts Elizabeth G

来源：Pharmacological Reports, 2012, 64(4): 960-964.

• heroin
• physical activity
• positive reinforcement
• rat
• self-administration

Background: The purpose of this study was to examine the effects of voluntary wheel running on the positive reinforcing effects of heroin in rats with an established history of drug self-administration.
Methods: Rats were assigned to sedentary (no wheel) and exercise (wheel) conditions and trained to self-administer cocaine under positive reinforcement contingencies. Rats acquiring cocaine self-administration were then tested with various doses of heroin during daily test sessions.
Results: Sedentary rats self-administered more heroin than exercising rats, and this effect was greatest at low and moderate doses of heroin.
Conclusion: These data suggest that voluntary wheel running decreases the positive reinforcing effects of heroin.

• 出版日期2012-8