A Simple and Efficient One-Pot Synthesis of Substituted Benzo[b]furans by Sonogashira Coupling-5-endo-dig Cyclization Catalyzed by Palladium Nanoparticles in Water Under Ligand- and Copper-Free Aerobic Conditions

作者：Saha Debasree; Dey Raju; Ranu Brindaban C^*

来源：European Journal of Organic Chemistry, 2010, 2010(31): 6067-6071.

DOI：10.1002/ejoc.201000980

• Cyclization
• Cross-coupling
• Palladium
• Nanoparticles
• Water chemistry

A simple and efficient procedure for the synthesis of 2-substituted benzo[b]furan derivatives has been developed by the reaction of 2-iodophenols and arylacetylenes in water catalyzed by palladium nanoparticles generated in situ in open air. The reaction does not require any additive, ligand, or co-catalyst. The reaction occurs through Sonogashira coupling of 2-iodophenols with phenylacetylenes followed by 5-endo-dig cyclization. A series of functionalized benzo[b]furan derivatives was obtained in high yields by this procedure.

• 出版日期2010-11