科研之友
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摘要
New Rh- and Pd-catalyzed regiodivergent and stereoselective intermolecular coupling reactions of imidazole derivatives with mono-substituted allenes are herein reported. Using a Rh-I/Josiphos system, perfect regioselectivities and high enantiomeric excess were obtained, while a Pd-II/dppf system gave linear products with high regioselectivities and high E/Z selectivities. This method permits the atom economic synthesis of valuable branched and linear allylic imidazole derivatives.
- 出版日期2014-2-17
