Anti-diabetic molecules from Cycas pectinata Griff. traditionally used by the Maiba-Maibi

作者：Laishram S; Sheikh Y; Moirangthem D S; Deb L; Pal B C; Talukdar N C; Borah J C^*

来源：Phytomedicine, 2015, 22(1): 23-26.

DOI：10.1016/j.phymed.2014.10.007

• Diabetes
• alpha-Glucosidase
• alpha-Amylase
• Cycas pectinata
• Maiba-Maibi

Bioactivity guided chemical investigation On active anti-diabetic constituents of the fruits of Cycas pectinata Griff. (FCP) characterized EAFr-5 as the most potent sub fraction which significantly reduced the blood glucose level to normal in STZ induced diabetic rats, It was shown to contain the biflavonoids amentoflavone (1) and 2,3-dihydroamentoflavone (2) which exhibited significantly high inhibitory potency against a-glucosidase (IC50 8.09 +/- 0.023 and 9.77 +/- 0.032 mu M, respectively) and alpha-amylase (IC50 73.6 +/- 0.48 and 39.69 +/- 0.39 mu M, respectively). This is the first report of bioactivity guided isolation of anti-diabetic constituents from the traditionally used fruits of Cycas pectinata Griff.

• 出版日期2015-1-15