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摘要
Purpose: F-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT) is the reference standard in staging of F-18-FDG-avid lymphomas; however, there is no recommended functional imaging modality for indolent lymphomas. Therefore, we aimed to compare the performance of whole-body magnetic resonance imaging (WB-MRI) with that of F-18-FDG PET/CT for lesion detection and initial staging in patients with aggressive or indolent lymphoma. @@@ Materials and methods: We searched the MEDLINE, EMBASE, and CENTRAL databases for studies that compared WB-MRI with F-18-FDG PET/CT for lymphoma staging or lesion detection. The methodological quality of the studies was assessed using version 2 of the "Quality Assessment of Diagnostic Accuracy Studies" tool. The pooled staging accuracy (mu) of WB-MRI and F-18-FDG PET/CT for initial staging and for assessing possible heterogeneity (chi(2)) across studies were calculated using commercially available software. @@@ Results: Eight studies comprising 338 patients were included. In terms of staging, the metaanalytic staging accuracies of WB-MRI and F-18-FDG PET/CT for Hodgkin lymphoma and aggressive non-Hodgkin lymphoma (NHL) were 98% (95% CI, 94%-100%) and 98% (95% CI, 94%-100%), respectively. The pooled staging accuracy of F-18-FDG PET/CT dropped to 87% (95% CI, 72%-97%) for staging in patients with indolent lymphoma, whereas that of WBMRI remained 96% (95% CI, 91%-100%). Subgroup analysis indicated an even lower staging accuracy of F-18-FDG PET/CT for staging of less FDG-avid indolent NHLs (60%; 95% CI, 23%-92%), in contrast to the superior performance of WB-MRI (98%; 95% CI, 88%-100%). @@@ Conclusion: WB-MRI is a promising radiation-free imaging technique that may serve as a viable alternative to F-18-FDG PET/CT for staging of (18)FDG-avid lymphomas, where F-18-FDG PET/CT remains the standard of care. Additionally, WB-MRI seems a less histology-dependent functional imaging test than F-18-FDG PET/CT and may be the imaging test of choice for staging of indolent NHLs with low F-18-FDG avidity.
