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摘要
PURPOSE: To evaluate the predictive ability of macular parameters defined in the significance map created using spectral-domain optical coherence tomography (SDOCT) for paracentral visual field defects in early glaucoma. %26lt;br%26gt;DESIGN: Prospective comparative study. %26lt;br%26gt;METHODS: We studied 78 early-glaucomatous eyes of 78 patients, who underwent SD-OCT and standard automated perimetry 10-2. Macular layer parameters included the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) + inner plexiform layer (IPL), and RNFL + GCL + IPL. The minimal distance between the area with abnormal (P %26lt; 1%) thickness and foveal center was defined as the shortest distance. A wider area of an abnormally thinned ( %26lt; 1%) region, within either an inferior or a superior hemicircle with a diameter of 6 mm centered at the fovea, was defined as the macular abnormal area. A circumpapillary RNFL parameter was defined in its 36 sectors. Areas under the receiver operating characteristic curves (ROCs) were calculated to discriminate between eyes with (n = 39) and without (n = 39) paracentral visual field defects in the central 5 degrees. %26lt;br%26gt;RESULTS: Measurement reproducibility was almost perfect in the macular parameters at P %26lt; 1% (intraclass correlation, 0.907-0.942). Areas under the ROC were significantly higher (P %26lt; 0.01) in the macular parameters (0.870-0.930), including the shortest distance of GCL + IPL/RNFL + GCL + IPL, and the macular abnormal area of RNFL/GCL + IPL/RNFL + GCL + IPL than in the circumpapillary RNFL parameter (0.676). When specificity was fixed at 90%, the shortest distance of GCL + IPL (area under the ROC = 0.874) and the macular abnormal area of RNFL (area under the ROC = 0.894) showed sensitivities greater than 50%. %26lt;br%26gt;CONCLUSIONS: Macular structural parameters defined on an SD-OCT significance map may be potentially useful predictors of the presence of paracentral scotoma.
- 出版日期2013-11
