Mixed micelles of amphiphilic drug promethazine hydrochloride and surfactants (conventional and gemini) at 293.15 K to 308.15 K: Composition, interaction and stability of the aggregates

作者：Kabir ud Din^*; Rub Malik Abdul; Naqvi Andleeb Z

来源：Journal of Colloid and Interface Science, 2011, 354(2): 700-708.

DOI：10.1016/j.jcis.2010.11.005

• Phenothiazine drug
• Promethazine hydrochloride (PMT)
• Critical micelle concentration (cmc)
• Conductivity
• Conventional surfactant
• Gemini surfactant

Micellization of an amphiphilic phenothiazine drug promethazine hydrochloride (PMT) in presence of conventional (CTAB and TTAB) as well as gemini (16-s-16 and 14-s-14, s = 4-6) cationic surfactants has been studied conductometrically at different temperatures. Critical micelle concentration values (cmc and cmc(id)) indicate mixed micelle formation among the two components. Micellar mole fractions of surfactants (X-1, X-1(M) and X-1(id)) show greater contribution of surfactants. Interaction parameter, beta, suggests attractive interactions in the mixed systems. The thermodynamic parameters suggest dehydration of hydrophobic part of the drug at higher temperatures.

• 出版日期2011-2-15