Administration of antioxidants in cancer: debate of the decade

作者：Khurana Rajneet Kaur; Jain Ashay; Jain Atul; Sharma Teenu; Singh Bhupinder^*; Kesharwani Prashant^*

来源：Drug Discovery Today, 2018, 23(4): 763-770.

DOI：10.1016/j.drudis.2018.01.021

Several randomized clinical trials have divulged that administration of antioxidants during chemotherapy decreases the effectiveness of treatment. Hence, the characteristic feature of this article is extensive assessment of putative benefits and potential risks of natural and synthetic antioxidant supplementation, administered with chemotherapy, based upon the available preclinical and clinical data. After analyzing mixed results, it was concluded that current FDA guidelines should be followed before supplementing antioxidants during cytotoxic treatment. Nevertheless, contradictory experimental animal models opposing human clinical trials discourage the concurrent administration of antioxidants ostensibly owing to the possibility of tumor protection and reduced survival.

• 出版日期2018-4