Mitochondrial calcium homeostasis as potential target for mitochondrial medicine

作者：Giorgi Carlotta; Agnoletto Chiara; Bononi Angela; Bonora Massimo; De Marchi Elena; Marchi Saverio; Missiroli Sonia; Patergnani Simone; Poletti Federica; Rimessi Alessandro; Suski Jan M; Wieckowski Mariusz R; Pinton Paolo^*

来源：Mitochondrion, 2012, 12(1): 77-85.

DOI：10.1016/j.mito.2011.07.004

• Mitochondria
• Calcium
• Aging
• Neurodegeneration
• Diabetes
• Cardiovascular and mitochondrial disorders

Mitochondria are crucial in different intracellular pathways of signal transduction. Mitochondria are capable of decoding a variety of extracellular stimuli into markedly different intracellular actions, ranging from energy production to cell death. The fine modulation of mitochondrial calcium (Ca2+) homeostasis plays a fundamental role in many of the processes involving this organelle. When mitochondrial Ca2+ homeostasis is compromised, different pathological conditions can occur, depending on the cell type involved. Recent data have shed light on the molecular identity of the main proteins involved in the handling of mitochondrial Ca2+ traffic, opening fascinating and ambitious new avenues for mitochondria-based pharmacological strategies.

• 出版日期2012-1