Secondary Responses to Altered Acid-Base Status: The Rules of Engagement

作者:Adrogue Horacio J; Madias Nicolaos E*
来源:Journal of the American Society of Nephrology, 2010, 21(6): 920-923.
DOI:10.1681/ASN.2009121211

摘要

Each of the four canonical acid-base disorders expresses as a primary change in carbon dioxide tension or plasma bicarbonate concentration followed by a secondary response in the countervailing variable. Quantified empirically, these secondary responses are directional and proportional to the primary changes, run a variable time course, and tend to minimize the impact on body acidity engendered by the primary changes. Absence of an appropriate secondary response denotes the coexistence of an additional acid-base disorder. Here we address the expected magnitude of the secondary response to each cardinal acid-base disorder in humans and offer caveats for judging the appropriateness of each secondary response.

  • 出版日期2010-6