An Evidence Based Strategy for Follow Up After Breast Conserving Treatment for Breast Cancer

作者：Kontos Michael^*; Roy Pratik; Rizos Demetrios; Hamed Hisham

来源：Journal of Surgical Oncology, 2011, 104(3): 223-227.

DOI：10.1002/jso.21747

• oncology
• recurrence
• surgery

Background and Objectives: Follow up for breast cancer patients aims at the timely detection of loco-regional recurrences and contralateral breast cancers (LRR). This study investigates the annual risk of LRR after breast conserving treatment (BCT) and the potential value of mammographic surveillance and/or routine clinical examination.
Methods: Data on 650 women who underwent BCT were obtained and LRR was divided into parenchymal and non-parenchymal. LRR-free and cumulative LRR-free rates were calculated. In patients where recurrence was diagnosed at a routine clinic visit and had negative mammography ("clinical detection only" group) were also separately examined.
Results: Median follow up was 115 months, range 9-196. Seventy-three patients had parenchymal and 16 nodal recurrence. The median probability of LRR was 1.4% and of parenchymal LRR was 1.32% per year, remaining constant for up to 168 months. The 16 patients in the "clinical detection only" group relapsed mainly during the first 2 years (annual risk 0.77% and 0.80%, respectively).
Conclusions: This study shows that the risk of parenchymal LRR remains constant for at least 14 years and is significant enough to warrant routine long-term follow up mammography. Routine clinical examination contributes significantly to the detection of LRR only for the first 2 years. J. Surg. Oncol. 2011;104:223-227.

• 出版日期2011-9-1