A short history of hemogenic endothelium

作者：Swiers Gemma; Rode Christina; Azzoni Emanuele; de Bruijn Marella F T R^*

来源：Blood Cells, Molecules, and Diseases, 2013, 51(4): 206-212.

DOI：10.1016/j.bcmd.2013.09.005

• Hemogenic endothelium
• Hematopoietic stem cell
• Microenvironment
• Hematopoiesis
• Endothelial to hematopoietic transition

Definitive hematopoietic cells are generated de novo during ontogeny from a specialized subset of endothelium, the so-called hemogenic endothelium. In this review we give a brief overview of the identification of hemogenic endothelium, explore its links with the HSC lineage, and summarize recent insights into the nature of hemogenic endothelium and the microenvironmental and intrinsic regulators contributing to its transition into blood. Ultimately, a better understanding of the processes controlling the transition of endothelium into blood will advance the generation and expansion of hematopoietic stem cells for therapeutic purposes.

• 出版日期2013-12