A novel approach for the direct determination of residual template molecules in molecularly imprinted polymer matrices

作者：Meier Florian; Elbert Sven M; Mizaikoff Boris^*

来源：Analytical Methods, 2012, 4(9): 2755-2758.

DOI：10.1039/c2ay25308a

With inductively coupled plasma optical emission spectroscopy (ICP-OES), this article introduces an analysis method enabling the direct quantitative determination of residual template molecules in molecularly imprinted polymer (MIP) matrices. ICP-OES was applied for the determination of residual iodine in MIPs prepared against the iodinated X-ray contrast agent iohexol. Prior to analysis, a microwave-assisted acidic oxidative digestion method was developed simultaneously enabling the digestion of the polymer matrix and the exhaustive oxidation of organically bound iodine. Excellent recovery rates and a high accuracy confirm the feasibility and utility of a microwave-assisted digestion with subsequent ICP-OES analysis for the determination of residual iodine in MIPs, and indicate the potential of this combination as a widely applicable monitoring tool for the efficiency of template extraction from MIP matrices.

• 出版日期2012-9