Appendectomy and Risk of Parkinson's Disease: A Nationwide Cohort Study With More Than 10 Years of Follow-Up

作者：Svensson Elisabeth^*; Horvath Puho Erzsebet; Stokholm Morten Gersel; Sorensen Henrik Toft; Henderson Victor W; Borghammer Per

来源：Movement Disorders, 2016, 31(12): 1918-1922.

DOI：10.1002/mds.26761

• appendectomy
• Parkinson's disease
• risk factor

Objectives: The appendix may be a key site for the initiation of Parkinson's disease (PD) pathology. We examined the hypothesis that appendectomy is associated with lower PD risk.
Methods: We used Danish medical and administrative registries to construct a cohort of all patients in Denmark with an operation code of appendectomy during 1980-2010 (n=265,758) and a matched general population comparison cohort (n=1,328,790). Using Cox regression, we computed hazard ratios and corresponding 95% confidence intervals for PD, adjusting for potential confounders and stratifying on age at appendectomy (<= 45 years / >45 years), sex, and follow-up time.
Results: During follow-up (>10 years), PD incidence was 0.19 and 0.15 per 1,000 person-years at risk in the appendectomy cohort and in the general population comparison cohort, respectively, yielding a slightly increased risk of PD (adjusted hazard ratio=1.14; 95% confidence interval 1.03-1.27). Findings were consistent after more than 20 years of follow-up and when stratified on age of appendectomy and sex.
Conclusion: Appendectomy was associated with a small increase in PD risk 10 or more years after surgery.

• 出版日期2016-12