Computing with Competition in Biochemical Networks

作者：Genot Anthony J^*; Fujii Teruo; Rondelez Yannick

来源：Physical Review Letters, 2012, 109(20): 208102.

DOI：10.1103/PhysRevLett.109.208102

Cells rely on limited resources such as enzymes or transcription factors to process signals and make decisions. However, independent cellular pathways often compete for a common molecular resource. Competition is difficult to analyze because of its nonlinear global nature, and its role remains unclear. Here we show how decision pathways such as transcription networks may exploit competition to process information. Competition for one resource leads to the recognition of convex sets of patterns, whereas competition for several resources (overlapping or cascaded regulons) allows even more general pattern recognition. Competition also generates surprising couplings, such as correlating species that share no resource but a common competitor. The mechanism we propose relies on three primitives that are ubiquitous in cells: multiinput motifs, competition for a resource, and positive feedback loops.

• 出版日期2012-11-13