Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study

作者：Muravska Alexandra; Germanova Anna; Jachymova Marie; Hajek Zdenek; Svarcova Jana; Zima Tomas; Kalousova Marta^*

来源：Clinical Biochemistry, 2011, 44(17-18): 1380-1384.

DOI：10.1016/j.clinbiochem.2011.09.015

• Intrahepatic cholestasis of pregnancy
• PAPP-A
• Preeclampsia
• Pregnancy-associated plasma protein A
• Single nucleotide polymorphism
• Gene
• Intrauterine growth restriction
• Preterm labor

Objectives: The aim of the study was to investigate genetic and biochemical background of PAPP-A (pregnancy-associated plasma protein A) in patients with risk pregnancies.
Design and methods: Five PAPP-A gene polymorphisms and PAPP-A maternal serum levels were studied together in 165 women in third trimester pregnancies complicated with threatening preterm labor (n=98), preeclampsia (n = 35), intrauterine growth restriction (n = 34) and ICP (intrahepatic cholestasis of pregnancy) (n = 15). 114 healthy pregnant women served as controls.
Results: Preeclamptic patients had significantly higher frequency of TT genotype of Cys327Cys polymorphism compared to controls (p<0.01). Patients with ICP had increased serum levels of PAPP-A compared to controls and correlation analysis showed significant relationship between PAPP-A and CRP (C-reactive protein) in the patients with intrauterine growth restriction (r = 0.49, p = 0.007).
Conclusion: Our study indicates the association of TT genotype of Cys327Cys polymorphism of the PAPP-A gene with preeclampsia. However, further study with larger groups of preeclamptic patients is needed to confirm our results.

• 出版日期2011-12