Multi-functionalized single-walled carbon nanotubes as tumor cell targeting biological transporters

作者：Yang Xiaoying^*; Zhang Zhuohan; Liu Zunfeng; Ma Yanfeng; Yang Rongcun; Chen Yongsheng

来源：Journal of Nanoparticle Research, 2008, 10(5): 815-822.

DOI：10.1007/s11051-007-9316-5

• single-walled carbon nanotubes
• tumor
• targeted drugs
• nanomedicine

Multi-functionalized single walled carbon nanotubes (SWNTs) were prepared and applied as tumor cell targeting biological transporters. A positive charge was introduced on SWNTs to get high loading efficiency of fluorescein (FAM) labeled short double strands DNA (20 base pairs). The SWNTs were encapsulated with the folic acid modified phospholipids for active targeting into tumor cell. The tumor cell-targeting properties of these multi-functionalized SWNTs were investigated by active targeting into mouse ovarian surface epithelial cells. The experimental results show that these multi-functionalized SWNTs have good tumor cell targeting property.

• 出版日期2008-5
• 单位南开大学; 天津医科大学