Training status and sex influence on senescent T-lymphocyte redistribution in response to acute maximal exercise

作者：Brown Frankie F; Bigley Austin B; Sherry Chris; Neal Craig M; Witard Oliver C; Simpson Richard J; Galloway Stuart D R^*

来源：Brain, Behavior, and Immunity, 2014, 39: 152-159.

DOI：10.1016/j.bbi.2013.10.031

• Immunosurveillance
• CD4(+) T-lymphocytes
• CD8(+) T-lymphocytes
• Trained
• Untrained

Purpose: Investigate training status and sex effects on the redistribution of senescent and naive T-lymphocytes following acute exercise. %26lt;br%26gt;Methods: Sixteen (8 male, 8 female) trained (18.3 +/- 1.7 yr) soccer players (Tr) and sixteen (8 male, 8 female) untrained (19.3 +/- 2.0 yr) controls (UTr) performed a treadmill running test to volitional exhaustion. Blood lymphocytes were isolated before (Pre), immediately post, and 1-h post-exercise for assessment of cell surface expression of CD28 and CD57 on CD4(+) and CD8(+) T-lymphocyte subsets. Plasma was used to determine cytomegalovirus (CMV) serostatus. %26lt;br%26gt;Results: Exercise elicited a redistribution of T-lymphocyte subsets. Senescent CD4(+) and CD8(+) T-lymphocytes increased by 42.4% and 45.9% respectively, while naive CD4(+) and CD8(+) T-lymphocytes decreased by 8.7% and 22.5% respectively in response to exercise. A main effect (P %26lt; 0.05) of training status was observed for senescent CD4(+), CD8(+) and naive CD8(+) T-lymphocytes: UTr had a higher proportion of senescent and a lower proportion of naive CD8(+) T-lymphocytes than Tr. A main effect (P %26lt; 0.05) of sex was observed in senescent CD4(+), CD8(+) and naive CD4(+), CD8(+) T-lymphocytes. Males had a higher proportion of senescent and lower proportion of naive T-lymphocytes than females. A sex-by-training status interaction (P %26lt; 0.05) was observed for the senescent and naive CD4(+) T-lymphocytes (but not CD8(+)) with the highest percentage of senescent and lowest percentage of naive T-lymphocytes observed in UTr males. CMV exerted a significant main covariate effect (P %26lt; 0.05) in the senescent and naive (P %26lt; 0.05) CD8(+) T-lymphocytes but not in the senescent and naive CD4(+) T-lymphocytes. %26lt;br%26gt;Conclusion: This study highlights important sex and training status differences in the senescent and naive T-lymphocyte redistribution in response to exercise that warrants further investigation.

• 出版日期2014-7