Age-specific reference range of prostate-specific antigen in a population-based single-center study in the north of China

作者：Nan, Li-Bin; Yin, Xiao-Tao; Li, Fang-Long; Shao, Zhi-Qiang; Xu, Yong; Guo, Gang; Tang, Jie; Gao, Jiang-Ping^*; Zhang, Xu

来源：International Journal of Clinical and Experimental Medicine, 2018, 11(2): 1376-1382.

• Age
• prostate cancer
• prostate-specific antigen

The goal of this study was to explore the relationship between age and serum prostate-specific antigen (PSA) levels in a healthy population in northern China and to establish the normal age-specific PSA reference levels. Clinical data were collected from healthy men who underwent routine health check-ups from July 2009 to September 2015. The enrolled men were classified into six groups by 10-year intervals, namely 30-39, 40-49, 5059, 60-69, 70-79, and 80-89. Correlations between age and normal PSA levels were analyzed. The 95th percentile range of each group was determined as the corresponding normal references of age-specific PSA, which were then compared with other studies from China and Western countries. A total of 24,194 men were included in this study. Serum PSA level was positively correlated with age (r=0.27, P<0.001). Normal serum PSA upper levels in each age group were 1.79 ng/mL, 1.92 ng/mL, 2.63 ng/mL, 4.41 ng/mL, 6.20 ng/mL, and 6.54 ng/mL, respectively. Age was correlated with normal serum PSA levels in general. Our results showed that the normal upper limit of age-specific PSA, of a population in northern China, was lower than that in Taiwan and in other Western countries.

• 出版日期2018
• 单位中国人民解放军总医院