Association between APOE polymorphisms and glioma risk

作者：Liu, Jian^*; Chen, Wei; Tao, Xinglong

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(3): 3962-3966.

• Apolipoprotein E (APOE)
• polymorphism
• glioma

Aims: This study aimed to investigate the association of apolipoprotein E (APOE) polymorphisms with the risk of glioma. Methods: Genotyping of APOE polymorphisms was performed on 132 patients with glioma and 130 healthy people with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The control group was matched with the cases by age and gender. The chi-square test was used to analyze the frequency of genotypes and alleles. The correlation intension between APOE polymorphisms and glioma was evaluated by odds ratios (OR) and 95% confidence intervals (CI). Results: The genotype frequencies of APOE polymorphism in the control group was in accordance with Hardy-Weinberg Equilibrium (HWE). Among APOE polymorphisms, E4/4 genotype had obviously higher frequency in cases than the control group and was associated with the increased risk of glioma (OR=2.598, 95% CI=1.039-6.493). Similarly, epsilon 4 allele might be also a risk factor (OR=1.679, 95% CI=1.103-2.554). However, genotype E3/3 and allele epsilon 3 played the protective role in the development of glioma (E3/3: OR=0.605, 95% CI=0.370-0.990; epsilon 3: OR=0.558, 95% CI=0.386-0.807). Conclusions: Allele epsilon 4 in APOE polymorphisms might be a risk factor for the occurrence of glioma, but epsilon 3 was a protective factor to be against glioma in Chinese study population.

• 出版日期2016
• 单位河北医科大学