科研之友
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摘要
Background: Angiopoietin-like protein 2 (Angptl2) is an adipokine that promotes inflammation and endothelial dysfunction of the vessels. The aim of this study was to investigate the relationship between serum Angptl2 level and chronic kidney disease (CKD). %26lt;br%26gt;Methods and Results: A total of 3,169 community-dwelling subjects aged 40 years were divided into quintiles by Angptl2 level. CKD was defined as the presence of albuminuria (urine albumin-creatinine ratio %26gt;= 30.0 mg/g) or decreased estimated glomerular filtration rate (eGFR %26lt;60 ml.min(-1).1.73 m(-2)). The odds ratio (OR) for the presence of CKD was calculated using a logistic regression model. The overall prevalence of CKD was 37.5%. The age- and sex-adjusted ORs for the presence of CKD increased with higher serum Angptl2 level. This trend remained significant after adjusting for known cardiovascular risk factors (%26lt;2.01 ng/ml: OR, 1.00 (reference); 2.01-2.48 ng/ml: OR, 1.67, 95% confidence interval [CI]: 1.24-2.24; 2.49-2.99 ng/ml: OR, 1.70, 95% Cl: 1.27-2.28; 3.00-3.65 ng/ml: OR, 1.78, 95% CI: 1.32-2.39; %26gt;= 3.66 ng/ml: OR, 1.79, 95% CI: 1.32-2.43; P-value for trend=0.001). Multivariate-adjusted ORs for the presence of albuminuria increased significantly with elevated serum Angptl2 (P-value for trend=0.004), while there was no evidence of a significant relationship between serum Angptl2 level and decreased eGFR (P-value for trend=0.08). %26lt;br%26gt;Conclusions: Elevated serum Angptl2 is associated with the likelihood of CKD in the general population.
- 出版日期2013-9
