An Efficient and Environmentally Benign Protocol for the 1,6-Michael Addition of Nitroalkanes to 3-Methyl-4-nitro-5-styrylisoxazoles in WERSA

作者：Kumar Nandigama Satish; Bheeram Vema Reddy; Mukkamala Saratchandra Babu; Rao L Chandrasekhara; Vasantha R

来源：ChemistrySelect, 2018, 3(6): 1915-1918.

DOI：10.1002/slct.201702788

• Baclofen
• 3-methyl-4-nitro-5-styrylisoxazoles
• Michael addition
• nitromethane
• WERSA

Herein, we describe a mild and convenient protocol for Michael addition of nitroalkanes to 3-methyl-4-nitro-5-styrylisoxazoles using neat "water extract of rice straw ash (WERSA)" as a catalyst and medium at room temperature. Method developed is simple to operate and yields range from good to excellent. This eco-friendly protocol also successfully used for the synthesis of pharmaceutical interest, such as gamma-nitrobutyricacid an intermediate for the preparation of Baclofen.

• 出版日期2018-2-14