科研之友
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摘要
Context: The precision of biological measurements may be affected by technical (methodological) and/or biological variability. Knowledge of the limits of measurement variability is critically important for the interpretation of serial studies. Such data for absolute flow quantification with cardia Positron Emission Tomography (PET) have not been previously reported. Methods and Results: To determine the test-retest precision within minutes (methodological variability) and days (both methodological and biological variability) in the determination of global myocardial blood flow by positron emission tomography (PET), the authors performed Rubidium-82 PET in 120 volunteers. Thirty-one subjects underwent a sequential (10 minutes apart) restrest- stress protocol (rest perfusion precision) on day 1 and 1-3 weeks later (day 2). The serial 10-minute scans quantified the test-retest methodological precision for measuring resting perfusion, and the repeat rest scan on different days assesses methodological plus biological variability. Eighty-nine subjects underwent a rest-stressstress protocol (stress perfusion precision) of day 1 and day 2, which involved a usual rest-stress acquisition followed by a second stress acquisition 12, 13, 14, 1,5 or 16 minutes after dipyridamole injection. Serial stress scans provided test-retest methodological precision for measuring stress perfusion, while repeat scans provided a measure of methodological and biological variability. The authors report that the test-retest methodological precision (coefficient of variance) for serial quantitative global myocardial perfusion minutes apart was +/- 10% (mean DSD at rest +/- 0.09, at stress +/- 0.23 cc/min/g), reflecting methodological variability, and for days apart was +/- 21% (mean DSD at rest +/- 0.2, at stress +/- 0.46 cc/ min/g), reflecting added biological variability. The authors also noted that the global myocardial perfusion at 8 minutes after 4-minute dipyridamole infusion is 10% higher than at standard 4 min after dipyridamole. Significance: This elegant study is the first of its kind to report the test-retest variability in coronary blood flow on PET imaging and provides valuable insight into the limits of technical and biological variability, which is important for serial imaging.
- 出版日期2017-4
